For those who have had polynucleotide (PN/PDRN) dermal injections (Nucleofill, Rejuran), and at least 3 months have passed, could you share if you see any hypopigmentation spots in the places where the product was injected?
Some 3 months ago, I got Nucleofill Strong injections for some acne scars. Immediately after and even a few days later, the injection spots were swollen and in a lighter color, but this is expected. There were a few spots where the injection spots were larger (for the larger, deeper scars), so in these places the swelling and the lighter color remained even after a week. It looked like this (image posted by u/leit_motif):
I did some microneedling over these spots, and it helped a lot. Now, in the past month, I have been looking at these spots more closely, and I noticed that they have a slight hypopigmentation. They are not fully white, just lighter than rest of the skin. And, interestingly, when I do microneedling over them now, they do not become red and there is no pinpoint bleeding. these spots kinda remind me of scar tissue. However, as opposed to hypopigmented scars, these injections spots are round/oval, so they are more visible. Now, I am not sure if this is permanent, but it kinda feels like it. To me it seems that there has been some fibroblast migration and therefore increased collagen (i.e. scar tissue) growth in these areas. But not in a good way, as it is noticable (not to others, but to me).
Yesterday I decided to research a bit more into it, and it appears that PN/PDRN actually has anti-melanogesis properties, as it suppresses tyrosinase activity (link to study). This is very interesting, but I wish I had known this prior.
So I was wondering if anyone else has noticed something similar? And whether or not this effect (at least the hypopigmentation, is likely permanent?
by Background_Crazy_180